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Anj Granieri
What PEM Really Is (It’s Not Just Fatigue)
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What PEM Really Is (It’s Not Just Fatigue) chronic illness education energy limiting illness mecfs mecfs recovery neuroimmune fatigue neuroimmune illness pem post exertional malaise Dec 15, 2025

If you have MECFS, you've probably heard of PEM — post-exertional malaise. PEM is the hallmark feature of ME/CFS, and one of the clearest ways clinicians distinguish it from other illnesses. PEM, as it is defined in ME/CFS, does not occur in other conditions in the same way.

However, the term post-...

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